Time-Dependent Protective Effects of Ginger on Paracetamol-Induced Nephrotoxicity in Rabbits
DOI:
https://doi.org/10.65420/sjphrt.v2i3.157Keywords:
Ginger, Paracetamol, Kidney, rabbitAbstract
This study was conducted to identify the physiological and histological changes in the rabbit kidney resulting from administering a single dose of paracetamol (750mg/kg) and to determine the protective role of ginger according to the time period. This study used 48 rabbits divided into 8 groups: negative control group, positive control group (paracetamol 750mg) and the remaining groups were given an aqueous extract of ginger at different concentrations (100,200,400) mg/kg and different periods (15days, 30days). The results showed that paracetamol caused kidney tissue damage, increase urea, creatinine and uric acid levels. Pre-dose of aqueous ginger extract (100,200,400) mg for 15 days improved the physiological and histological changes. While prior dosing with ginger (100,200,400) mg/kg for 30days caused a severe decrease in uric acid levels compared with the positive control group.
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