Microbiological Study of Antibiotic Susceptibility Patterns in Clinical Bacterial Isolates in Ajdabiya City

Abstract

The current microbiological study explores antibiotic resistance patterns in clinical bacterial isolates in Ajdabiya, Libya, where bacterial infections remain a leading cause of death with mortality rates reaching 30%. The study aimed to identify the most prevalent bacterial species and measure their sensitivity to a variety of common antibiotics. Diverse clinical samples, including swabs, urine, and body fluids, were collected from the laboratories of the Higher Institute of Medical Sciences and Technology. Results revealed microbial diversity including Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter spp., and the Enterobacteriaceae family, in addition to Gram-positive bacteria like Staphylococcus aureus. Susceptibility testing showed alarming resistance rates toward several classes of antibiotics, particularly in isolates associated with community-acquired infections. The study also demonstrated that therapeutic efficacy is concentrated in actively growing bacteria, while latent forms pose a significant medical challenge. The paper concludes that the spread of resistance genes and genetic transfer mechanisms among strains necessitates strict surveillance strategies and the development of targeted therapeutic protocols to limit the depletion of available treatment options. The study recommends the need to enhance awareness regarding the rational use of antibiotics and conduct in-depth genetic research to understand the composition of resistance genes in the local environment.